AL-AMYLOIDOSIS is the most common type of amyloidosis and involves proteins called light chains.
Light chains make up part of the structure of immunoglobulins (antibodies) which play an important part in the immune system. They are produced by plasma cells in the bone marrow.
In AL- amyloidosis, abnormal plasma cells make excessive amounts of abnormal light chain proteins. Instead of forming immunoglobulin, they become misfolded and deposit as amyloid in various organs of the body.
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Symptoms and complications of AL-amyloidosis vary from patient to patient, depending on the organs involved and the extent of damage caused by the amyloid deposits. Any organ apart from the brain can be affected.
Signs and symptoms of AL-amyloidosis may include: